Vitamine preparation



T1 ITODIaWinB.

P tented June 1925.

UNITED STATES Isaac .n Ennis, or. rucxenon. NEW YORK.

PATENT OFFICE.

' vrrammn rnnrmmorr.

To all whom it may concern.

- My inventmn'relates to vitamine-contai'ningpbodies,particularly to bodies containin water-soluble fVitamines and intende foruse as food compounds. It is invention to so incorporate an object of my body, particularly of the the vitamine water-soluble variety, in the food --comand substantially permanent, a further ob- 'pounclthat'the same will berendered stable ject of my invention .being' to provide a method for so stabilizing vitamines, especially when present in food or similar compounds.

By way of ez' z'ample, I shall describe illustrative embodiments of the product and method .of my invention in the accompany-' ing specification, it being] clearly understood that my invention; is not limited to the specific embodiments thereof herein set forth for purposes'of illustration'only.

ploy [water-soluble vitamine bodymore particularly 'a highly concentrated vita mine body,..preferably in powder form,

such, for'example' as may be obtainedlfrom living yeast cells. S.uch a. body and the method ;-of preparing the. same are .fully nding 'ap'phcation, Ser;

set forth, inmyco -No. 347,503, filed ecember 26,1919.

' This .vitamine body is alight, yellow brown, ver hygroscopic powder,

- ing a perfectly :clear solution.-

sou

havin -'-an It is readily 'so'lublein cold-water, produc- .It is freely but is less ble in 52% ethyl alcohol,

soluble in ethyl alcohol stronger-than and substantially insoluble in absolute 'a'l-q cohol. Its aqueoussolutions are light brown to dark brown, according 'to' the concentration of. the" solution. Its solutions have a taste similar to extractof beefand have other properties ofa mixture-of propeptones and aminofacids' It s "sub-'1 stantially free from coagulable proteins and ivesj reactions for the amino groups, but, does not ive thefbmret. reaction. Solui.

'tates" with, I however, does not preclpltate' everything vitamine extracting the dried cohol, anhydrous acetone and p p tion from atmospheric conditions. "As my starting material I prefer to em-' odor and aste similar to *extract ,of eefL;

' sons, be ut up 1n such a form, or combmed r on s-i -tions of ,t 's product'give. copious precipi f; p' ospho-tungstic acid, which,"

- Application-filed December 28, 1919. Serial no. 347,502

from the solution. Its aqueous solutions are also .partly precipitated by solutions of barium hydroxide, silver nitrate, mercuric chloride or lead acetate. The dry powder, when burned, leaves about'12l5% of ash.

One methodof preparing the foregoing substance as. set forth in my copending application referred to above comprises, briefly, boiling said cells with water acidified with about one per cent of acetic acid, filtering ,-drying the filtrate in vacuo and. at a low temperature,thereafter,

product with an aqueous solution of ethyl. alcohol of about 52% strength, filtering, and thereafter reducing the ltrate to dryness, furtherextracting this residue with 80% to filtering, and dehydrating tlie-,.. .,precipitate with suchdrying agents as anhydrous alanhydrous ether.

ethyl alcohol, 1

' I. have discovered that vitamins bodies,

particularly water-soluble vitamine? bodies such as the substance described and claimed .in my copending application-referred to above, require a certain amount of protec- -It is also evident that a vita- The i they absorb mine body such as the substance described in my copending application, should in View of the fact thatit is intended to be administered byrelatively unskilled erwith suc other substances as to .make its administration sim le and the dosage exact. I have discovere that sugar may be used :to'preserve the vit-amine bodies without .deleter-iously afiectin them. ,For the purose, I use prefera ly a relatively nonyg'roscopic'sugar and in View of the fact that the vitamine bodies are principally intended for use in infant feeding, I preferably employ a lactose or sugar of milk.

ablj; an e ual amount by weight, of galac- When desired, a variable quantity, prefertos'e, may e added. -The proportions genl erally used are four to ten parts by wel ht J'ofsugar tofone part by weight of the vltamine body. The materials are intimately creased by ture, as by making tablets of the same by mixed, this intimate mixture being desirable to enclose and surround the particles of the vitamine bodies by the protecting sugar. a

I have also discovered that the mixture of sugar and vitamine body, water-soluble variety, such as described and claimed in my copending application referred to above, is rendered. more stableand the preservative action of the sugar indensifying or pressingthe mixmolding under pressure, which also renders the preparation more convenient to use and administer.

It will be evident that by mixing the vitamine body and the sugar in the mans ner set forth above, that the powder and tablet produced by the process described, and particularly the tablet form, affords a very easy and convenient method of admin istration by relatively unskilled person.

For instance, in infant food, where the addition of a given quantity of sugar of milk especially of the to the food is prescribed, this amount may be added Without taking into account the vitamine bodies, since they have previously been mixed with the sugar of milk in the. desired proportion and a physician may prescribe the use of sugar of milk containing a greater or less quantity of vitamine bodies, as required. When added to a liquid food, the combined sugar of milk and vitamine bodies are readily water soluble and can be readily dissolved in liquid foods, such as natural or prepared milks forming a clear solution. a

. What I claim is:

1. A food compound comprising a'vita'- mine body and equalparts of lactose and galactose 2. A' food compoundlcompr'ising a vitamine body derived from living yeast cells and equal, parts of lactose and galactose.

In testimony whereof I have signed my name to this specification this 24th day of December, 1919. u w ISAAC. F. HARRIS. a 

